Studies on Experimental Models

Model. to. Study. Interactions. Between. Oxidative. Stress. and. Inflammation. Christina Yfanti, Søren Nielsen, Camilla Scheele, and Bente Klarlund Pedersen Abstract Inflammation is involved in the pathogenesis of insulin resistance, ...

Author: Samar Basu

Publisher: Springer Science & Business Media

ISBN: 9781607619567

Category: Science

Page: 698

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There is a widespread consensus that use of antioxidants as a therapeutic approach may counteract free radical mediated pathologies. However, the role of antioxidants in normal physiology and redox signaling is still in its infancy. Since oxidative stress is related to various diseases and pathologies, scientists are eager to study the disease in humans, but it is not always ethical to study all the aspects of the disease in humans. Thus, it becomes mandatory to study the disease process and the mechanisms behind it through experimental models which generally involve animals, in vitro/cell culture studies, primates and even humans to a certain extent. Studies on Experimental Models contains data on the experimental models or review of such models of oxidative stress in various diseases. It is structured into six sections, which are as follows: diabetes, cardiovascular, neurology, ocular diseases, toxicology/environmental and in vitro/tissue culture. Each section presents a sketch of models in humans, animals and in vitro methods. Taken together, they comprise a valuable reference for basic and clinical scientists, one aimed at contributing to the advancement of oxidative stress research using appropriate animal models.

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